TNFα-senescence initiates a STAT-dependent positive feedback loop, leading to a sustained interferon signature, DNA damage, and cytokine secretion

Renuka Kandhaya-Pillai; Francesc Miro-Mur; Jaume Alijotas-Reig; Tamara Tchkonia; James L. Kirkland; Simo Schwartz

doi:doi:10.18632/aging.101328

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Research Paper Volume 9, Issue 11 pp 2411—2435

TNFα-senescence initiates a STAT-dependent positive feedback loop, leading to a sustained interferon signature, DNA damage, and cytokine secretion

Figure 3. Activation of the canonical JAK/ STAT pathway. Pathway analysis using IPA reveals canonical activation of STAT1 acts as a central regulator for JAK/ STAT-mediated interferon response genes during TNFα-induced senescence. The red symbols represent up-regulated genes, with the intensity of node color indicating degree of up-regulation and white indicating genes absent from the list. Shape of nodes denotes functions of gene products.