Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs

James A. McCubrey; Kvin Lertpiriyapong; Linda S. Steelman; Steve L. Abrams; Li V. Yang; Ramiro M. Murata; Pedro L. Rosalen; Aurora Scalisi; Luca M. Neri; Lucio Cocco; Stefano Ratti; Alberto M. Martelli; Piotr Laidler; Joanna Dulińska-Litewka; Dariusz Rakus; Agnieszka Gizak; Paolo Lombardi; Ferdinando Nicoletti; Saverio Candido; Massimo Libra; Giuseppe Montalto; Melchiorre Cervello

doi:doi:10.18632/aging.101250

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Review Volume 9, Issue 6 pp 1477—1536

Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs

Figure 4. Effects of curcumin on chromatin structure. An overview of the effects of CUR on demethylation of genes and the effects on the various genes are indicated. Red arrows indicate induction of an event; black closed arrows indicate suppression of an event. M = methylation of a sequence.