Sodium fluoride (NaF) induces the splenic apoptosis via endoplasmic reticulum (ER) stress pathway <i>in vivo</i> and <i>in vitro</i>

Huidan Deng; Ping Kuang; Hengmin Cui; Lian Chen; Qin Luo; Jing Fang; Zhicai Zuo; Junliang Deng; Xun Wang; Ling Zhao

doi:doi:10.18632/aging.101150

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Research Paper Volume 8, Issue 12 pp 3552—3567

Sodium fluoride (NaF) induces the splenic apoptosis via endoplasmic reticulum (ER) stress pathway in vivo and in vitro

Figure 6. Effect of NaF on protein expression levels of ATF6, p-IRE1, p-PERK, p-eIf2a and ATF4 in cultured splenic lymphocytes at 24 h (A) and 48 h (B). (a) The western blot assay. (b-f) Quantitative analysis of protein expression. Data are presented with the means ± standard deviation, * p < 0.05, ** p < 0.01, compared with the control group. Data were analyzed by the variance (ANOVA) test of the SPSS 19.0 software.