Curcumin supplementation improves vascular endothelial function in healthy middle-aged and older adults by increasing nitric oxide bioavailability and reducing oxidative stress

Jessica R. Santos-Parker; Talia R. Strahler; Candace J. Bassett; Nina Z. Bispham; Michel B. Chonchol; Douglas R. Seals

doi:doi:10.18632/aging.101149

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Research Paper Volume 9, Issue 1 pp 187—208

Curcumin supplementation improves vascular endothelial function in healthy middle-aged and older adults by increasing nitric oxide bioavailability and reducing oxidative stress

Figure 4. Forearm blood flow (FBF) area under the dose-response curve (AUC) in response to acetylcholine (FBF_ACh) without (-) or with (+) NG monomethyl-L-arginine (L-NMMA; left) and nitric oxide-dependent dilation (right) at week 0 and after 12 weeks of placebo or curcumin supplementation. Data are mean±SE; *P<0.02 vs. corresponding group week FBF_ACh (left); Group by time P=0.04, *P=0.03 vs. curcumin week 0 (right).