Research Paper Volume 8, Issue 12 pp 3486—3497
Proteins that accumulate with age in human skeletal-muscle aggregates contribute to declines in muscle mass and function in Caenorhabditis elegans
Figure 3. Nematodes exposed to RNAi targeting human muscle-aggregate orthologs have increased muscle mass. Muscle was stained with rhodamine-tagged phalloidin in wild-type worms (strain N2, N=25 – 35 per group) as illustrated for control (A) and RNAi-exposed worms (targeting uev-1 in panel B). Staining intensity (mean ± SEM) of muscle mass is presented (C). Significance of differences from control: *P<0.05; **P<0.02; ***P<0.001; ****P<0.0001.