Research Paper Volume 8, Issue 12 pp 3486—3497
Proteins that accumulate with age in human skeletal-muscle aggregates contribute to declines in muscle mass and function in Caenorhabditis elegans
Figure 2. Nematodes exposed to RNAi targeting human muscle-aggregate orthologs have fewer and smaller protein aggregates. Fluorescent aggregates (Q40::YFP foci) are shown in strain AM141 (N=40–65 worms per group) after maintenance from hatch on bacteria carrying either control (empty vector) (A) or uev-1 RNAi knockdown (B) expression plasmid. Histograms show the mean ± SEM of the number of aggregate foci (C) and fluorescent intensity per aggregate (D). Significance of differences from control: *P<0.05; **P<0.02; ***P<0.001; ****P<0.0001.