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Research Paper Volume 8, Issue 12 pp 3321—3340

RelA NF-κB subunit activation as a therapeutic target in diffuse large B-cell lymphoma

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Figure 2. Prognosis for p65 hyperactivation in diffuse large B-cell lymphoma (DLBCL). (A) In overall DLBCL, high p65 nuclear expression (p65high, ≥50% nuclear expression) was associated with unfavorable progression-free survival (PFS). The adverse prognostic impact was significant in patients with an international prognostic index score (IPI) ≤2. (B) In patients with stage I/II DLBCL, p65high correlated with significantly poorer PFS. Among p65high DLBCL patients, disease stages did not show further prognostic impact. (C) p65high correlated with significantly poorer PFS in patients with GCB-DLBCL and patients with wild-type TP53 (WT-TP53).