Research Paper Volume 8, Issue 11 pp 3120—3130

Figure 1. Effect of rapamycin on glucose clearance and insulin sensitivity in 5 diabesity models. (A) Rapamycin does not exacerbate glucose intolerance in 5 glucose intolerant strains. (B) Rapamycin improves insulin sensitivity in the insulin-resistant NcZ10, BKS-db/db, and TH strains. Two or three B6 controls were tested with each strain (cumulative data shown, n = 13–16) to serve as positive controls for the glucose and insulin injections, as quality controls, and for reference values. P values are given for repeated measures MANOVA (n = 5–6 per strain/treatment group except for NcZ10, n = 11).