Research Paper Volume 8, Issue 11 pp 2988—3008

Transgenerational programming of longevity through E(z)-mediated histone H3K27 trimethylation in Drosophila

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Figure 5. Early-life period as the critical time to extend longevity via H3K27me3. (A) Experimental design, and (B) survival curves for virgin males. The flies were subjected to one of five dietary and EPZ-6438 manipulations as illustrated in (A). N=98−99 for longevity analyses. Statistical analyses and median lifespan were summarized in Table S4.