Research Paper Volume 8, Issue 11 pp 2927—2935

Figure 3. Correlation between MDH1 and neurodegenerative biomarker proteins. In sCJD patients, a positive correlation was obtained between MDH1 level and the tau (r=0.27; p=0.029*; n=72), 14-3-3 (r=0.60; p=0.03*; n=13), NSE (r=0.39; P=0.01*; n=40) levels (A, C, D). MDH1 levels concentrations correlated negatively to Aβ1-40 (r=-0.47, p=0.04*, n=20) (F). No correlation was detected between MDH1 and p-tau (r=0.17, p=0.31, n=38), S-100B (r=0.26; p=0.08; n=43), Aβ1−42 (r=-0.33, p=0.09, n=26) levels and the Aβ1-42/Aβ1-40 ratio (r=0.08, p=0.7, n=20) (B, E, G, H). All correlation studies were computed by using the non-parametric Spearman correlation test (two-tailed) in a confidence interval of 95%. A p-value < 0.001 is considered as extremely significant (***), < 0.01 as very significant (**), < 0.05 as significant (*) and ≥ 0.05 as not significant (ns).