Research Paper Volume 8, Issue 10 pp 2590—2602
Article has an altmetric score of 17

Haploinsufficiency of the Myc regulator Mtbp extends survival and delays tumor development in aging mice

class="figure-viewer-img"

Figure 4. Long-lived Mtbp heterozygous mice exhibit normal systemic physiology. (A) The mean number of pups birthed from Mtbp+/+ x Mtbp+/- crosses by each female Mtbp+/+ (+/+; n=20 females; 328 total pups; black) and Mtbp+/- (+/-; n=25 females; 569 total pups; gray) mouse was recorded and averaged (p=0.2247). (B-H) Healthy long-lived (29 months) +/+ (n=5) and +/- (n=8) male mice were starved for 5 hours. (B) The nose-to-rump length was recorded and averaged (p=0.9999). (C) After sacrifice, the femurs were isolated and their length measured with electronic calipers and averaged (p=0.7160; n=7 for +/- group due to loss of one femur from bilateral fracture from collection). (D-H) Blood was collected and serum isolated. Circulating levels of (D) IGF-1 (p=0.4175), (E) cholesterol (p=0.3572), (F) triglycerides (p=0.4037), (G) blood glucose (p=0.7116) and (H) insulin (p=0.6963) were measured. P values calculated with student’s t-tests, and error bars are SEM.