Research Paper Volume 8, Issue 12 pp 3185—3208
Human exceptional longevity: transcriptome from centenarians is distinct from septuagenarians and reveals a role of Bcl-xL in successful aging
Figure 7. C. elegans baring a gain of function mutation in the Bcl-xLorthologced-9(n1959) show an increased longevity. (a) ced-9 and Bcl-xL protein domains by BCL-XL 3D modeling. (b) Representative wildtype and ced-9(n1959) gain of function allele longevity curve and Table with the data for two replicates (Exp.1: experiment 1; Exp.2: experiment 2). ced-9(n1950) animals show increased mean and maximum lifespan (LS) and double the percentage of alive animals at 25 days compared to wildtype. Statistical test refers to mean LS.