Research Paper Volume 8, Issue 12 pp 3185—3208

Figure 2. Sub-network analysis of genes specifically regulated by centenarians or septuagenarians versus young subjects indicates the relevance of interferon gamma (IFNG). Sub-network of genes regulated by interferon gamma (IFNG) in mononuclear cells from centenarians (a) or septuagenarians (b) versus young subjects. Data reported in Supplementary Figures 2–7 show other sub-network analyses that point to TNF, TCR, SP1, TGFB1, and IL-32 as genes with regulatory importance that are specific for centenarians. Sub-networks are generated by connecting genes to their neighbors in the database (ResNet 8.0; 2010Q4 Mammal). Sub-networks with the best P-value of 0.05 enrichment P-value cutoff were selected.