Figure 1.Overview of the method used to optogenetically induce cellular senescence in vitro. (A) Model illustrating how mild genotoxic stress can induce cellular senescence-like proliferation arrest (according to [30]). (B) Overview of the method for inducing cellular senescence using the genetically encoded photosensitizers tandem KillerRed (tKR) and miniSOG that were targeted to chromatin.
