Research Paper Volume 8, Issue 10 pp 2392—2406
Transgenic expression of cyclooxygenase-2 (COX2) causes premature aging phenotypes in mice
Figure 6. H&E stained sections of pancreas from COX2 transgenic mice (TG) showing the loss of the pancreatic acini, the increase of the metaplastic pancreatic ducts with dysplastic changes, peri-ductal fibrosis, and mononuclear inflammatory cell infiltration in the highly vascularized fibrotic stroma. Hyperplasia of the Langerhans islets was also noticed. Scale bar=100 μm