Research Paper Volume 8, Issue 10 pp 2392—2406

Figure 3. (A) Longevity in control (n=23) and COX2 transgenic (n=25) mice. (B) H&E stained sections of hind leg skeletal muscle from 22-week-old control (CT) and COX2 transgenic (TG) female littermates. Cross sections of the extensor digitorum longus (EDL) muscle are shown. Scale bar=100 μm (C) Frequency distribution of skeletal muscle fiber cross-sectional area (CSA) between control (CT) and COX2 transgenic (TG) mice. (D) Heart weight/body weight (HW/BW) ratios in tamoxifen-induced control (CT) and COX2 transgenic (TG) male littermates at the age of 22 weeks. HW/BW ratios in COX2 transgenic mice were significantly higher than those in control mice (paired t-test, p<0.001). (E) Quantitative assessment of fat content by X-ray densitometry of control (CT) and transgenic (TG) mice (n=5). (F) White blood cell (WBC) counts in tamoxifen-induced control (CT) and COX2 transgenic littermates (paired t-test, *: p<0.05, **: p<0.01, n=4). (G) The opacity of cornea developed in COX2 transgenic (TG) mice.