Research Paper Volume 8, Issue 10 pp 2392—2406

Figure 2. Cross-sections of dorsal skin from 20-week-old control (A, C, and F) and COX2 transgenic (B, D, and G) female littermates. Epidermis (E), dermis (D), adipose under the dermis (A), and muscle (M) are indicated. The COX2 transgenic skin exhibits sebaceous gland hyperplasia and a decrease in subcutaneous fat and muscle. Scale bar=100 μm (E) Quantification of the thickness of subcutaneous fat in control and COX2 transgenic mice (***: p<0.001). (H) A representative photo of 20- week-old COX2 transgenic and age-matched control male mice at 20 days after hair removal on dorsal area. (I) Quantification of hair re-growth in control and COX2 transgenic mice (***: p<0.001).