Research Paper Volume 8, Issue 10 pp 2370—2391

A cross-sectional study of male and female C57BL/6Nia mice suggests lifespan and healthspan are not necessarily correlated

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Figure 9. Few measures of healthspan are correlated with one another. Measures correlated among female mice include (A) grip strength and dark activity (p = 0.0003, R = 0.454); (B) grip strength and percent fat (p = 0.0037, R = 0.405); (C) percent fat and body mass, (D) rotarod performance (latency to fall) and body mass (p = 0.0006, R = -0.443); (E) dark and light phase metabolic rate (p < 0.0001, R = 0.880); (F) dark phase and resting metabolic rate (p < 0.0001, R = 0.823) and (G) light phase and resting metabolic rate (p < 0.0001, R = 0.860). Measures correlated among male mice include (H) grip strength and dark activity (p = 0.0003, R = 0.454); (I) grip strength and percent fat (p = 0.0037, R = 0.405); J. percent fat and body mass; (K) dark phase activity and body mass; (L) rotarod performance (latency to fall) and body mass (p = 0.0006, R = -0.443); (M) rotarod performance and dark phase activity; (N) dark and light phase activity; (O) percent fat and light phase activity; (P) dark phase activity and metabolic rate; (Q). dark and light phase metabolic rate (p < 0.0001, R = 0.880); (R) dark phase and resting metabolic rate (p < 0.0001, R = 0.823) and (S) light phase and resting metabolic rate (p < 0.0001, R = 0.860).