Research Paper Volume 8, Issue 10 pp 2370—2391

Figure 7. Grip strength was reduced in older mice compared to younger mice; performance on the tail flick test did not differ between age groups. (A) Female grip strength was reduced in older females compared to younger ones (p < 0.0001). Grip strength was greater in 4-month -old females than 28 and 32-month -olds (p = 0.0002 and p< 0.0001, respectively) and did not differ from 20-month-olds (p =0.431). Grip strength measured in 20-month-old females was greater than that of 32-month -olds (p < 0.0001), but not 28-month -olds (p = 0.0942). (B) Grip strength was similar in 4 and 20-month old males (p > 0.999); both had greater grip strength than 28-month -old (p = 0.001 and p = 0.024, respectively) and 32-month -old males (p = 0.001 and p = 0.021, respectively). Grip strength was similar in 28 and 32-month old males (p > 0.999) (C, D) Performance on the tail flick test did not differ between age groups in female (p = 0.422) or male (p = 0.370) mice. Post-hoc tests subject to Bonferroni correction for multiple comparisons. Grip strength sample size: Females n = 20, 20, 31 and 27 for 4, 20, 28 and 32 months; Males n = 14, 14, 18 and 14 for 4, 20, 28 and 32 months. Tail flick sample size: Females n = 20, 20, 26 and 26 for 4, 20, 28 and 32 months; Males n = 22, 20, 31 and 27 for 4, 20, 28 and 32 months.