Research Paper Volume 8, Issue 9 pp 2023—2038
Increased expression of long-noncoding RNA ZFAS1 is associated with epithelial-mesenchymal transition of gastric cancer
Figure 1. LncRNA ZFAS1 was up-regulated in gastric cancer tissues and was associated with TNM stage, cancer invasion, lymph node metastasis and cancer diameter. (A) ZFAS1 was highly expressed in GC tissues compared to paired non-tumor tissues (P < 0.0001). (B) ZFAS1 expression levels in different clinical stage of gastric cancer (P = 0.0053). (C) Up-regulation of lncRNA ZFAS1 was associated with tumor invasion (P = 0.0043). (D) Up-regulation of lncRNA ZFAS1 was associated with lymph node metastasis (P = 0.0059). (E) Up-regulation of lncRNA ZFAS1 was associated with cancer diameter (P = 0.0209). The relative expression level was calculated using 2-ΔCT method. **, P < 0.01, *, P < 0.05. Statistical analysis were conducted by Wilcoxon test (A) and Mann-Whitney U test (B, C, D and E).