Research Paper Volume 8, Issue 10 pp 2308—2323
SIRT6 delays cellular senescence by promoting p27Kip1 ubiquitin-proteasome degradation
Figure 10. Model of SIRT6 regulating p27 during cellular senescence. SIRT6 deacetylates p27, which promotes the ubiquitination of p27 and increases the degradation of p27 by proteasome. Then SIRT6 can repress cellular senescence.