Research Paper Volume 8, Issue 8 pp 1759—1780
Scavengers of reactive γ-ketoaldehydes extend Caenorhabditis elegans lifespan and healthspan through protein-level interactions with SIR-2.1 and ETS-7
Figure 5. SIR-2.1 preservation does not affect mitochondrial function. (A, B) SA administration does not alter oxygen consumption rate (OCR). OCR of N2 WT and SIR-2.1 mutation in the presence and absence of SA was measured over time via XF Seahorse Biosciences Analyzer™. Data are expressed as means ± SEM from four independent experiments. P = 0.1 and P = 0.3, respectively. (C, D) SA treatment does not alter mtDNA integrity. Analysis of mtDNA content collected over time from lysates of SA-treated N2 WT and SIR-2.1 mutant animals. Data are expressed as means ± SEM from four independent experiments. P = 0.1 and P = 0.6, respectively.