Research Paper Volume 8, Issue 7 pp 1485—1512

Figure 4. Manhattan plots for EWAS results. (A) The y-axis shows log (base 10) transformed p-values resulting from a meta analysis across 3 lobes (frontal, parietal, and occipital lobe). Meta analysis p-value resulted from the limma R function that also included the batch as covariate. EWAS results (Kruskal Wallis test) for individual lobes can be found in (B) frontal lobe, (C) occipital lobe, (D) parietal lobe. The horizontal line corresponds to a Bonferroni corrected significance level of p=0.05/500000. The statistical analysis ignored the dependence between observations arising from the fact that multiple samples were collected from the same individual. Therefore, the p-values should be considered as descriptive (rather than inferential) measures.