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Research Paper Volume 8, Issue 8 pp 1670—1689

BMI1 inhibits senescence and enhances the immunomodulatory properties of human mesenchymal stem cells via the direct suppression of MKP-1/DUSP1

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Figure 6. BMI1 directly suppresses DUSP1 by binding to the promoter of DUSP1. (A) Chromatin immunoprecipitation was performed to examine BMI1 and H3K27me3 binding to the DUSP1 and p16INK4a promoter of GFP- and BMI1-overexpressing hUCB-MSCs. (B) ChIP-quantitative PCR assay results for the DUSP1 promoter region in BMI1-up-regulated hUCB-MSCs. Data represent the means ± SEM (C) Schematic representation of the function of BMI1 in hUCB-MSCs in increasing their immunomodulatory properties and protecting the cell from senescence.