Long-term moderate calorie restriction inhibits inflammation without impairing cell-mediated immunity: a randomized controlled trial in non-obese humans

Simin N. Meydani; Sai K. Das; Carl F. Pieper; Michael R. Lewis; Sam Klein; Vishwa D. Dixit; Alok K. Gupta; Dennis T. Villareal; Manjushri Bhapkar; Megan Huang; Paul J. Fuss; Susan B. Roberts; John O. Holloszy; Luigi Fontana

doi:doi:10.18632/aging.100994

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Research Paper Volume 8, Issue 7 pp 1416—1431

Long-term moderate calorie restriction inhibits inflammation without impairing cell-mediated immunity: a randomized controlled trial in non-obese humans

Figure 2. Change in the number of white blood cells and lymphocytes following 2 years of calorie restriction in humans. Panel (A) baseline values of white blood cells for ad libitum (AL) and calorie-restricted (CR) groups were 5.9 × 10³/μl and 6.0 × 10³/μl, respectively. Panel (B) baseline values of lymphocytes for both AL and CR groups were 1.8 × 10³/μl. Data are mean (SE). The P value comparisons are for AL and CR groups at indicated time points.