Research Paper Volume 8, Issue 7 pp 1384—1397
FOXM1 regulates proliferation, senescence and oxidative stress in keratinocytes and cancer cells
Figure 6. A FOXM1- and p63-dependent positive feedback loop. FOXM1 and p63, due to the positive feedback loop, are both involved in the regulation of oxidative stress responses and proliferation in normal epithelial cells. FOXM1 acts as a sensor and regulator of oxidative stress to protect normal and tumor proliferating cells.