N-acetyl-cysteine prevents age-related hearing loss and the progressive loss of inner hair cells in γ-glutamyl transferase 1 deficient mice

Dalian Ding; Haiyan Jiang; Guang-Di Chen; Chantal Longo-Guess; Vijaya Prakash Krishnan Muthaiah; Cong Tian; Adam Sheppard; Richard Salvi; Kenneth R. Johnson

doi:doi:10.18632/aging.100927

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Research Paper Volume 8, Issue 4 pp 730—750

N-acetyl-cysteine prevents age-related hearing loss and the progressive loss of inner hair cells in γ-glutamyl transferase 1 deficient mice

Figure 3. Dwg/dwg mice show large IHC loss in the apical 70% of cochlea at 6-9 months of age. (A–B) Mean % OHC and IHC loss (+/− SEM, n=6) as a function of % distance from the apex of the cochlea for 9 month old +/+, +/dwg and dwg/dwg mice. Frequency-place map for mouse cochlea is shown on abscissa. Note large IHC loss in the apical 70% of the cochlea and little OHC loss in dwg/dwg mice and also minimal OHC and IHC loss in +/+ and +/dwg mice. (C–D) Mean % OHC and IHC loss in dwg/dwg mice (20% distance intervals, +/− SEM, n=6) as a function of % distance from the apex of the cochlea in 1, 3, 6 and 9 month old dwg/dwg mice. Frequency-place map for mouse cochlea shown on abscissa [124].