Research Paper Volume 8, Issue 5 pp 1083—1098

Figure 7. Reduced motor and memory tasks in aged Col6a1−/− mice. (A) Rotarod test analysis on 7-month-old and 23-month-old wild-type and Col6a1^−/− mice. The time on the rod (in sec) is reported in the graph. Aged Col6a1^−/− animals show reduced time to fall from rotarod compared to matched wild-type animals (***, P<0.001; n = 4). (B) Ledged beam test results from 23-month-old wild-type and Col6a1^−/− mice. The histograms report the mean distance before the initial foot fault, the number of total hindpaw foot faults, and the time spent to reach the end of the beam (*, P<0.05; n = 4). (C) Y-maze test results from 23-month-old wild-type and Col6a1^−/− mice. The histograms report the percentage of alternation and the number of entries (*, P<0.05; n = 8-15).