Research Paper Volume 8, Issue 2 pp 382—393
Telomere shortening leads to earlier age of onset in ALS mice
Figure 3. Telomerase deficiency affects disease course of SOD1G93A-transgenic mice. (A) Kaplan-Meier plot of disease onset. G4 mTerc−/−;SOD1G93A mice show a 13 day earlier disease onset compared to SOD1G93A-mice. Disease onset: G4 mTerc−/−;SOD1G93A-mice 116 days ± 12.256, SOD1G93A-mice 129 ± 11.800. (B) Kaplan-Meier plot of age of fist paresis. G4 mTerc−/−;SOD1G93A mice with telomerase deficiency show hindlimb-paresis 6 day earlier compared to SOD1G93A-mice. Age of fist paresis: G4 mTerc−/−;SOD1G93A-mice 142 days ± 6.482, SOD1G93A-mice 148 ± 5.958. (C) Kaplan-Meier plot of survival. Survival of G4 mTerc−/−;SOD1G93A mice with telomerase deficiency is reduced about 9 days compared to SOD1G93A-mice. Survival: G4 mTerc−/−;SOD1G93A-mice 160 days ± 10.995, SOD1G93A-mice 169 ± 10.060. G4 mTerc −/−;SOD1G93A (n= 54), SOD1G93A (n=47). Mice of both genders were monitored daily.