Figure 3 — Prevention of diet-induced hepatic steatosis and hepatic insulin resistance by second generation antisense oligonucleotides targeted to the longevity gene mIndy (Slc13a5)

Research Paper|Volume 7, Issue 12|pp. 1086–1093

Prevention of diet-induced hepatic steatosis and hepatic insulin resistance by second generation antisense oligonucleotides targeted to the longevity gene mIndy (Slc13a5)

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Figure 3.(A) Glucose infusion rate during the hyperinsulinemic-euglycemic clamp (HEC) is increased in mIndy ASO treated rats. (B) Trend for reduced hepatic glucose production during the HEC in the mIndy ASO treated rats. (C) Suppression of hepatic glucose production during the HEC was increased in mIndy ASO treated rats as compared to the control group. All data are mean ± SEM, N=10 for each group; significances by double sided t-test.