Mitochondria-targeted antioxidant SkQ1 improves impaired dermal wound healing in old mice

Ilya A. Demyanenko; Ekaterina N. Popova; Vlada V. Zakharova; Olga P. Ilyinskaya; Tamara V. Vasilieva; Valeria P. Romashchenko; Artem V. Fedorov; Vasily N. Manskikh; Maxim V. Skulachev; Roman A. Zinovkin; Olga Yu. Pletjushkina; Vladimir P. Skulachev; Boris V. Chernyak

doi:doi:10.18632/aging.100772

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Research Paper Volume 7, Issue 7 pp 475—485

Mitochondria-targeted antioxidant SkQ1 improves impaired dermal wound healing in old mice

Figure 7. Effect of SkQ1 on EA.hy926 cell migration in scratch wound assay at 24 h. The effect of 20 nM SkQ1, and conditioned medium (c.m.) from fibroblasts treated with 20 nM SkQ1. (a) Representative micrograph; bar, 60 μm. (b) Analysis of cell migration. The inhibitor of TGFβreceptor was added to scratch wound assay where indicated. Data are presented as mean ± SEM; N=4;*P < 0.05 for c.m. from SkQ1-treated versus untreated fibroblasts.