Figure 2.Renal gene expression of key regulators of mitochondrial biogenesisKidney mRNA expression of Pgc1α (A), Ampk (B), Sirt1 (C), Nrf2 (D) and CoxIV (E) in male and female of wild-type (WT) and liver-specific growth hormone receptor knockout (LiGHRKO) mice. Each group consists of 7 animals. The data from real-time PCR were normalized by the housekeeping gene β2-microglobulin (B2M) and shown as a relative expression. Values are means ± SEM. a, b – values that do not share the same letter in the superscript are statistically significant (p<0.05). * – p<0.05 vs. male mice (the significance for sex). There are the following significant p values: Ampk: 0.041, Sirt1: 0.003.
