Liver-specific deletion of <i>Ppp2cα</i> enhances glucose metabolism and insulin sensitivity

Li Xian; Siyuan Hou; Zan Huang; An Tang; Peiliang Shi; Qinghua Wang; Anying Song; Shujun Jiang; Zhaoyu Lin; Shiying Guo; Xiang Gao

doi:doi:10.18632/aging.100725

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Research Paper Volume 7, Issue 4 pp 223—232

Liver-specific deletion of Ppp2cα enhances glucose metabolism and insulin sensitivity

Figure 5. Effects of wortmannin on glucose of Ppp2cα^loxp/loxp: Alb and WT: Alb mice. (a) GTT and AUC of over fasted Ppp2cα^loxp/loxp: Alb and WT: Alb mice treated with wortmannin lasted 4weeks. (b) Immunoblot analysis with antibodies to Akt, phosphor-Akt (pSer⁴⁷³ and pThr³⁰⁸) was examined in Ppp2cα^loxp/loxp: Alb and WT: Alb mice after injection with saline or insulin after 4 weeks wortmannin treatment. Data were analysed by two-tailed Student's t test (*p < 0.05).