Liver-specific deletion of <i>Ppp2cα</i> enhances glucose metabolism and insulin sensitivity

Li Xian; Siyuan Hou; Zan Huang; An Tang; Peiliang Shi; Qinghua Wang; Anying Song; Shujun Jiang; Zhaoyu Lin; Shiying Guo; Xiang Gao

doi:doi:10.18632/aging.100725

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Research Paper Volume 7, Issue 4 pp 223—232

Liver-specific deletion of Ppp2cα enhances glucose metabolism and insulin sensitivity

Figure 4. Enhanced insulin sensitivity in Ppp2cα^loxp/loxp: Alb mice. (a, b) Western blot of insulin signaling involved Akt pathway in the liver (a) and muscle (b). Livers and skeletal muscle of overnight fasted mice on chow were isolated 5mins after 1U/kg insulin treatment. (c) Relative expression of G₆P, PEPCK, and PGC1α mRNAs normalized against 36B4 mRNA levels, measured by Q-PCR in livers from fasted overnight mice. Data were analyzed by two-tailed Student's t test (*p < 0.05, ***p < 0.001).