Figure 4.Analysis of expression of genes that regulate regeneration and remodeling in BM-MMSC from HD and HF patients(A) Visualization of analysis of RT2-PCR expression array results: the blue color bars represent clusters of upregulated genes that control tissue regeneration at different levels; (B) Validation of upregulation of Tgf-beta superfamily genes in HF-derived BM-MMSC; n=10-16, *p<0.02, **p<0.01; (C) Validation of upregulation of extracellular matrix components and remodeling enzymes in HF-derived BM-MMSC; n=10-16; *p<0.001, **p<0.01, ***p<0.05; (D) Validation upregulation of cellular adhesion molecules and regulators of epithelial-to-mesenchymal transition in HF-derived BM-MMSC; n=10-16; *p<0.02; **p<0.002. All data are presented as mean +/− SEM.
