Research Paper Volume 6, Issue 11 pp 975—988
Iron promotes protein insolubility and aging in C. elegans
Figure 5. CaEDTA extends healthspan and lifespan in C. elegans. (A) 2.5 mM CaEDTA exposure from day 1 of adulthood significantly increases motility of 5 day-old animals. (B) Transient exposure to CaEDTA from day 1 of adulthood delays age-related decline of movement in wildtype animals in a dose-dependent manner. (C) Exposure to 2.5 mM CaEDTA for 24 hours increases thermotolerance in wild-type animals. (D) Kaplan-Meyer curve of N2 wildtype worms exposed to 2.5 mM CaEDTA from day 1 of adulthood. Metal chelation significantly increases lifespan (p<0.001, Log-rank, Mantel cox).