Research Paper Volume 6, Issue 11 pp 975—988

Figure 2. Iron supplementation increases susceptibility to toxicity in models of protein aggregation. (A) Kaplan-Meyer curves of wild-type animals exposed to 15 mM FAC from day 1 of adulthood. Iron supplementation significantly decreases lifespan (p<0.0001, Log-rank, Mantel-cox). (B) Iron supplementation increases proteotoxicity in an Aβ expressing transgenic strain after 120 hours of exposure (p<0.0001, Student's t-test). (C, D) Iron supplementation increases the number of polyglutamine inclusions and (E) increases onset of muscle dysfunction in a model of polyglutamine disease after 48 hours of exposure (p<0.0001, p=0.0007 respectively, Student's t-test). Plots are representative of three independent experiments. Error bars, SD.