Research Paper Volume 6, Issue 9 pp 742—754
Rapamycin-induced metabolic defects are reversible in both lean and obese mice
Figure 6. (A) Body weight of C57BL/6 males fed low fat (circles) or high fat (triangles) diets either with (solid) or without (open) encapsulated rapamycin (eRAPA). (B) Total fat content (left) and fat-free content (right) of mice in A. For all, symbols represent average (± SEM) values for n=6 mice. Downward arrow indicates time point of cessation of eRAPA treatment. F and p values given for repeated measures ANOVA testing the effect of eRAPA for the indicated diet. Asterisks indicate significant difference at time point between eRAPA and control for given diet from post-hoc analysis of ANOVA.