Research Paper Volume 6, Issue 8 pp 690—704
hNAG-1 increases lifespan by regulating energy metabolism and insulin/IGF-1/mTOR signaling
Figure 2. hNAG-1 transgenic mice have improved insulin sensitivity. (a), Mean body length of female hNAG-1 and Wt mice in both lines (n=6~8). (b-d), Mean serum levels of growth hormone (b), IGF-1 (c), insulin and leptin (d) in terminal blood of hNAG-1 and Wt mice on LFD and HFD (n=10). e, Insulin tolerance test on old (>95 wk) 1398 female hNAG-1 Tg mice and Wt mice (n=8~9). Data are presented as mean ±SE. a, p<0.05, b, p<0.01 and c, p<0.001 as determined by Student's t-test.