Research Paper Volume 6, Issue 8 pp 621—644
D-beta-hydroxybutyrate extends lifespan in C. elegans
Figure 9. βHB extends lifespan in a similar manner as DR and requires AAK-2, SIR-2.1, and CBP-1. (A) βHB does not extend lifespan of AMPK mutant aak-2(TG38) worms, (B) sir-2.1(ok434) worms, or (C) eat-2(ad1116) worms. (D) Additionally, βHB does not extend the lifespan cbp-1 RNAi knockdown N2 worms.