Research Paper Volume 6, Issue 8 pp 621—644

Figure 10. βHB protects against glucose toxicity and proteotoxicity. (A) Treatment with βHB partially protects against 50 mM glucose-induced reduction of lifespan in N2 worms. (B) Survival of the CL4176 strain of C. elegans expressing Aβ in muscle following temperature upshift. Treatment with βHB increases the time to paralysis (log-rank p < 0.001). βHB-treated mean lifespan = 29 hours, untreated control mean lifespan = 26 hours. The curves are generated from the results of six assays (n > 500 for both groups). (C) Treatment with βHB decreases α-synuclein-GFP aggregation in the NL5901 strain GFP fluorescence readings were taken on day 8 of worm lifespan. Data are represented as mean +/− SEM. (log-rank p < 0.001) (D) 20 mM βHB did not protect against the shortened lifespan induced by human TDP-43 overexpression when the worms were grown at 16°C.