Research Paper Volume 6, Issue 7 pp 575—586

Figure 3. Lifelong GH activity predicts senescence-associated gene expression in WAT. (A) Expression of p16, p21, and IL6 in WAT from 18-month old female Snell dwarf and age-matched non-mutant (NM) littermates. (B) Expression of p16, p21, and IL6 in WAT from 18-month old female GHR-/- and age-matched wild-type (WT) littermates. C. Expression of p16, p21, and IL6 in WAT from 10-month old female bGH and age-matched wild-type (WT) controls. D. Expression of p16, p21, and IL6 in WAT from 19-month old female GH-injected (GH-inj.) and age-matched saline-injected (Saline-inj.) controls. E. Expression of p16, p21, and IL6 in WAT from female 24 month and 3 month old mice. Data were analyzed by Student's t-test and are expressed as mean ± SEM of 4 mice per group for A & E and 6 mice per group for B-D. ^*P<0.05; ^$P<0.005.