Research Paper Volume 6, Issue 5 pp 399—413

Age-related changes in tissue macrophages precede cardiac functional impairment

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Figure 1. Age-dependent decline in proportion of Mrc1+ cTMs expressing high levels of Cx3cr1. (A) Representative contour scatter plots of GFP+ and/or Mrc1+ cTMs from 2, 8 or 34 week old Cx3cr1GFP/+mouse hearts (left, middle and right panels respectively). Dotted boxes demarcate Mrc1+GFPhi and Mrc1+GFPlo cTMs. (B) Decrease in proportion of Mrc1+GFPhi cTMs (O) and increase in Mrc1+GFPlo cTMs (⋄) with age (left and right panels, respectively)