Research Paper Volume 6, Issue 4 pp 311—319

Figure 3. Pathological assessment after long-term proBNP over-expression in aged spontaneously hypertensive rats (SHRs) with established HHD. The major clinical signs found in euthanized rats are listed. (A) A representative image of a SHR with pleural effusion. Note the chest cavity filled with clear liquid (right panel). (B) A representative image of a control SHR demonstrating hepatic steatosis. A higher magnification of the fatty yellow liver is shown in a right panel. (C) Mason's Trichrome staining of heart sections of controls and adeno-associated virus (AAV) vector-treated rats. Note prominent connective tissue deposits (stained in blue) in control rats, even though those control rats were younger than AAV9-treated rats. (D) A representative image of atrial thrombus (upper panel) and trichrome staining of the atrial thrombus (lower panel).