Figure 1 — Hexosamine pathway but not interstitial changes mediates glucotoxicity in pancreatic β-cells as assessed by cytosolic Ca2+ response to glucose

Research Paper|Volume 6, Issue 3|pp. 207–214

Hexosamine pathway but not interstitial changes mediates glucotoxicity in pancreatic β-cells as assessed by cytosolic Ca²⁺ response to glucose

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Figure 1.Four major pathways of glucose metabolism underlying glucotoxicity. Azaserine inhibits GFAT. GFAT; glutamine: fructose-6-phosphate amidotransferase, DHAP: dihydroxyacetone phosphate, DAG: diacylglycerol, AGE: advanced glycation product.