Figure 5.No effect of uterine tumors on lifespan(A) Uterine tumors are not seen in glp-4(bn2) mutants (raised at 15°C to L4 then shifted to 25°C). Uterine classes 2-5 indicate presence of tumors. Each dot corresponds to a uterine status measurement. (B)glp-4 does not suppress mdl-1 effects on lifespan (for statistics, see Table S2, trial 1). (C) FUdR suppresses formation of uterine tumors at 50μM or greater. Stars represent a significant difference to worms of the same genotype in the absence of FUdR. No significant difference in tumor levels between N2 and mdl-1 were detected at this age at any FUdR concentration. * 0.01 < p < 0.05; ** 0.001 < p < 0.01; *** p < 0.001 (Wilcoxon Mann test). (D) 50μM FUdR does not suppress mdl-1 shortevity or increase N2 lifespan (for statistics, see Table S2, trial 1). (E) Effect of mdl-1 on glp-4 longevity (for statistics, see Table S2, trial 2).
