Research Paper Volume 6, Issue 1 pp 58—69

Figure 4. Hoppel insertion extends life span. (A) Representative survivorship plots for female and male Hoppel genotypes isolated from Oahu lines with either no chromosome containing Hoppel in Indy (−/−; in black); one chromosome containing Hoppel in Indy (+/−; in red) or both chromosomes containing Hoppel in Indy (+/+; in green) grown on two different foods (1.5N and 0.5N diet) [29]. Survivorship plots for Captain Cook and Hidalgo lines are in Fig. S2 and tests for survivorship and maximum life span are in Table S2. (B) Reaction norms of median life span for Male (red) and Female (blue) Oahu, Captain Cook and Hidalgo lines for each of three different Indy genotypes (no chromosome containing Hoppel in Indy −/−; one chromosome containing Hoppel in Indy +/− or both chromosomes containing Hoppel in Indy +/+) grown on two different types of food (1.5N and 0.5N diet) [29]. (C) The effect of the dosage of each Hoppel containing Indy chromosome on life span extension for inter-strain hybrids between the Oahu, Captain Cook and Hidalgo strains represented as the mean of median life span extension in days for Males (red) and Females (blue) flies. Left of the green dotted line is the mean of the median life span extension for inter-strain hybrids in which both chromosomes have a Hoppel element in Indy (+/+) as compared to inter-strain hybrids with no Hoppel in Indy (−/−). Right of the green dotted line are shown the increase in mean of the median life span upon addition of each chromosome containing Hoppel in Indy; inter-strain hybrids with both chromosomes having a Hoppel in Indy (+/+) as compared to one chromosome having a Hoppel in Indy (+/−) and inter-strain hybrids with one chromosome having a Hoppel in Indy (+/−) as compared to inter-strain hybrids with no chromosome having a Hoppel in Indy (−/−) (Table S3). These data represent 96 separate inter-strain hybrid life spans including two different types of food (1.5N and 0.5N diet) [29]. Error bars are S.E.M.