Research Paper Volume 5, Issue 10 pp 759—769
A DNA synthesis inhibitor is protective against proteotoxic stressors via modulation of fertility pathways in Caenorhabditis elegans
Figure 5. FUdR is dependent on oocytic maturation to confer stress resistance. A,B, FUdR-treatment has no significant effect on fem-1(hc17) or fem-3(e2006) mutants while it significantly extends wild-type N2 survival at 35°C. C-E, FUdR-treatment significantly extends fer-6(hc6), fer-1(hc24), and spe-9(hc88) survival at 35°C to a similar extent as wild-type N2 animals. F, FUdR-treatment significantly extends the survival of mated fem-3(e2006) mutants at 35°C. All temperature-sensitive mutants were reared at 25°C and shifted to 35°C as young adults. In all experiments, FUdR was used at 100 μg/ml.