Research Paper Volume 5, Issue 10 pp 759—769
A DNA synthesis inhibitor is protective against proteotoxic stressors via modulation of fertility pathways in Caenorhabditis elegans
Figure 2. FUdR upregulates transcriptional expression of the heat shock regulated chaperone hsp16.2 after heat stress. A, B, Fluorescent photomicrographs of animals expressing the transcriptional reporter, phsp16.2::GFP, after heat stress in the absence or presence of FUdR (100 μg/ml). Worms were heat stressed for 1 hour at 35°C and GFP expression was analyzed approximately 5 hours later. C, Quantification of GFP expression from A, B. FUdR-treatment significantly increases GFP levels compared to untreated control animals. (**=p<0.0001, Student's t-test)