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Online ISSN: 1945-4589
Research Perspective
|
Volume 5, Issue 7
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pp. 490–494
M(o)TOR of aging: MTOR as a universal molecular hypothalamus
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Figure 1
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Figure 1.
MTOR-dependent geroconversion to senescence
When cell cycle is arrested, MTOR drives geroconversion, leading to cellular hypertrophy, hyperfunction, loss replicative/regenerative potential and resistance to signals such as insulin.
